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International Journal of Behavioral Nutrition and Physical Activity

○ Springer Science and Business Media LLC

Preprints posted in the last 30 days, ranked by how well they match International Journal of Behavioral Nutrition and Physical Activity's content profile, based on 15 papers previously published here. The average preprint has a 0.02% match score for this journal, so anything above that is already an above-average fit.

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Validity and reliability of the Japanese version of the Movement Behaviour Questionnaire-Child (MBQ-C) for assessing active play, screen time, and sleep in preschool children

Komura, K.; Yamakita, M.; Kyan, A.; Inoue, S.; Nagano, M.; Takenaga, R.; Breugelmans, R.; Jego, E. H.; Trost, S. G.

2026-09-29 public and global health 10.64898/2026.09.28.26364096 medRxiv
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Background: Valid and feasible measures of preschoolers' 24-hour movement behaviours are needed for population-level research. We developed a Japanese version of the Movement Behaviour Questionnaire-Child (MBQ-C) and evaluated its measurement properties and practicality. Methods: After translation and cross-cultural adaptation following the COSMIN procedure, including cognitive interviews, we evaluated the questionnaire in a cross-sectional validation study of Japanese children aged 3-6 years. Concurrent validity was assessed against hip-worn accelerometry and a 7-day diary; we also examined test-retest reliability, measurement error, agreement between response formats and modes, and practicality (completion time, burden, and clarity). Analyses used Spearman correlations, intraclass correlation coefficients, the SEM, smallest detectable change (SDC), and Wilcoxon signed-rank tests. Results: Of 208 children, 170 provided valid accelerometer and diary data for the concurrent-validity analysis, and 187 completed the MBQ-C for the questionnaire-based analyses. Concurrent validity was weak for active and energetic play (Spearman {rho} = 0.12-0.26), strong for total screen time (0.78-0.85), and moderate for total sleep (0.48-0.58). Test-retest reliability was moderate to good (ICC, 0.66-0.81), and within-child variability was lowest for sleep (CV 3%) and highest for the physical activity items (21-33%). The open- and closed-ended versions showed no significant differences; paper-electronic agreement was good for screen time and sleep but poor for active play. Completion took approximately 6-9 minutes, with low reported burden. Findings were robust in sensitivity analyses. At the group level, SDC for a mean was SDCind/{surd}N: 119.8/{surd}N, 74.0/{surd}N, 112.6/{surd}N, and 92.5/{surd}N min/day for active play, energetic play, total screen time, and total sleep, respectively (N = number of children surveyed). The systematic differences between the two test-retest occasions were +15.7, +6.5, +4.0, and -5.4 min/day, respectively. Conclusions: The Japanese MBQ-C is a practical option for assessing preschoolers' active play, screen time, and sleep at the group level. By quantifying its group-level measurement error, this study provides benchmarks for interpreting group-level differences and change, supporting the use of the MBQ-C in surveillance and evaluation of programmes delivered at scale.

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Effects of a 500-day LPG cookstove and fuel intervention delivered during gestation and infancy on height-for-age (HAZ) and stunting at ages 2, 3, 4 and 5 years: findings from a follow-up study of the multi-country HAPIN trial

Kalam, M. A.; Sinharoy, S. S.; Steenland, K.; Thompson, L. M.; Diaz-Artiga, A.; McCracken, J. P.; Balakrishnan, K.; Aravindalochanan, V.; Garg, S.; Rosa, G.; Ndagijimana, F.; Jabbarzadeh, S.; Johnson, M.; Pillarisetti, A.; Kearns, K.; Lovvorn, A. E.; Ramakrishnan, U.; Peel, J.; Clasen, T. F.

2026-10-21 public and global health 10.64898/2026.10.16.26365712 medRxiv
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Objective Reducing household air pollution exposure during gestation and infancy may have longer-term benefits for child linear growth. We examined whether a liquefied petroleum gas (LPG) cookstove and fuel intervention delivered during gestation and infancy could improve height-for-age Z scores (HAZ) and reduce the risk of stunting at ages 2-5 years in India, Rwanda, and Guatemala. Materials and method The Household Air Pollution Intervention Network (HAPIN) was a randomized controlled trial that enrolled ~3200 pregnant women across Guatemala, India, Peru, and Rwanda. Women in the intervention group received an LPG cookstove and free fuel during pregnancy and until the infant reached 12 months of age. Following the HAPIN trial, we continued following children in Guatemala, India, and Rwanda (N=2169) and measured child height at ages 2, 3, 4, and 5 years (HAPIN 2.0). As prespecified in the study protocol, we used mixed-effects models, as well as linear and log-binomial regression, within the intention to treat (ITT) framework, to evaluate the interventions effect on HAZ and stunting. Subgroup analyses were performed to assess effect modification by child sex, maternal height, and intervention country. Results The intervention reduced gestational exposures to particulate matter (PM2.5: 80.7 vs 117.5 {micro}g/m3), carbon monoxide (CO: 1.3 vs 2.0 ppm), and black carbon (BC: 8.6 vs 12.1 {micro}g/m3) and infancy exposures (PM2.5: 36.9 vs 113.2 {micro}g/m3; CO: 0.60 vs 2.2 ppm). Post-trial PM2.5 exposure were similar between arms: 99.9 vs 98.7 {micro}g/m3. We found no statistically significant effect of the intervention on repeated measures of HAZ ({beta} = -0.06, 95% CI: -0.16, 0.03 p=0.204), annual HAZ, stunting, nor severe stunting at any age during the follow-up. There was no statistically significant effect modification by subgroups. Conclusion Despite substantial reductions in air pollution exposures during the trial, the LPG intervention did not improve growth or reduce stunting risk from ages 2 through 5 years in this multi-country cohort. These findings, consistent with prior results of the lack of effects on growth through 12 months, provide additional evidence that a clean cooking intervention alone may not be sufficient to address childhood stunting in low-resource settings. Future exposure-response analyses will supplement these ITT analyses.

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Sex-Specific Associations of Added Sugars and Fructose Exposure Across the First 1,000 Days With Body Composition at 24 Months

Fortin-Miller, S. A.; Gajewski, B. J.; Carlson, S. E.; Colombo, J.; Christifano, D. N.; Sullivan, D. K.; Hull, H. R.

2026-10-19 nutrition 10.64898/2026.10.16.26365755 medRxiv
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Background: Added sugars during early development may influence adiposity, but whether associations vary by developmental timing and child sex is unclear. Objectives: To determine whether child sex modifies associations of added sugars and fructose exposure from pregnancy through 24 months with body composition at 24 months. Methods: This secondary longitudinal analysis included 130 mother-child dyads. Maternal diet was assessed during mid-pregnancy and child diet at 2wk and 6mo (infancy), and 12mo and 24mo (toddlerhood). Multivariable regression tested sex-by-exposure interactions for anthropometric outcomes; 42 children had usable dual-energy X-ray absorptiometry (DXA) data. Results: Prenatal added sugars were more positively associated with percentage body fat and total and regional fat mass in girls than in boys. Prenatal fructose was more positively associated with waist circumference in boys. During infancy, added sugars were more positively associated with percentage body fat and total and regional fat mass in boys, whereas fructose was more positively associated with fat-free mass in girls. Conclusions: Associations of early-life sugars exposure with body composition varied by developmental timing and child sex. Findings from the smaller DXA subset are exploratory and require replication but suggest that susceptibility to early dietary sugars may differ across developmental windows.

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Estimated Free-Living Energy Balance and Perceived Physical and Psychological Stress in Japanese Male University Students: A 28-Day Observational Study

Yoshida, A.

2026-10-14 nutrition 10.64898/2026.10.13.26365271 medRxiv
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Background: Whether whole-body energy balance is associated with perceived stress in young adults is unclear. Aim: To examine associations of estimated free-living energy balance with physical and psychological stress during 28-day monitoring. Methods: This secondary analysis of an observational study included 18 Japanese male university students with at least 14 valid accelerometer days (at least 600 min/day). Energy intake was estimated using the Brief-type Self-administered Diet History Questionnaire; total energy expenditure was estimated from accelerometry plus resting metabolic rate. Physical and psychological stress were assessed before and after monitoring using 100-mm visual analog scales. Baseline-adjusted linear regression was used. Summary: Mean energy balance was -79 kcal/day (SD 531). Energy balance was not clearly associated with post-monitoring physical stress (B = 0.067 per 100 kcal/day, 95% CI -1.604 to 1.737; p = 0.933) or psychological stress (B = 0.314, 95% CI -2.571 to 3.199; p = 0.820). No clear association between estimated free-living energy balance and post-monitoring stress was detected.

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Development of a comprehensive database of markers of ultra-processing to identify ultra-processed food in the UK according to the Nova classification

Dicken, S. J.; van Tulleken, D.

2026-09-25 nutrition 10.64898/2026.09.24.26363859 medRxiv
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Growing evidence links ultra-processed food intake according to the Nova classification with poor health, yet no comprehensive database of additives and food substances of non-culinary use that are markers of ultra-processing exists for the UK. Building the database involved seven steps: (1) obtaining all approved additives in the UK, (2) retrieving all of their technical functions, (3) coding each technical function as cosmetic (marker of ultra-processing) or non-cosmetic (not a marker of ultra-processing), (4) adding 'flavour extracts', 'natural flavourings', and 'flavourings', (5) excluding additives as ultra-processing markers if they served fortification purposes, or were a herb/spice, and (6) adding food substances of non-culinary use defined as markers of ultra-processing in the Nova classification. Lastly, (7) two UPF definitions were constructed based on the ambiguity/overlap of additive technical functions from previous approaches. The database is freely accessible for researchers to improve consistency in using the Nova classification in the UK.

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School staff and university instructors perceptions of barriers and facilitators of whole-grain consumption among children in Thailand: qualitative findings.

Paisanvit, N.; Ponprachanuvut, P.; Chammari, K.; Raethong, N.; Srisangwan, N.; Keeratichamroen, A.; Wang, S.; Tong, H.; Rai, R. K.; Srichamnong, W.; Bromage, S.; Matsuzaki, M.

2026-09-25 nutrition 10.64898/2026.09.22.26363746 medRxiv
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Thailand is experiencing a rapid rise in childhood obesity, increasing the risk of early-onset non-communicable diseases. Although whole grains support weight management and reduce non-communicable diseases risk, consumption remains low in Thailand and is insufficiently addressed in the Thai Food-Based Dietary Guidelines. Whole grains are also rarely included in the National School Lunch Program. Given its high participation rate, the school lunch program represents a strategic platform for increasing whole-grain intake and fostering lifelong healthy eating habits. This study aimed to identify facilitators and barriers to increasing whole-grain provision in Thai elementary schools from the perspectives of adult stakeholders We conducted in-depth interviews guided by the Integrated Behavioral Model with 19 teachers and contracted school cooks from two Thai elementary schools, and with 10 faculty and staff members at Mahidol University. Interviews explored perceived norms regarding student whole grain consumption, attitudes toward whole grain, and perceived facilitators and barriers to whole grain provision in schools. Data were analyzed using framework analysis, combining the Integrated Behavioral Model-informed thematic categorization with inductive coding. Transcripts were independently coded by two researchers to develop an Integrated Behavioral Model-grounded conceptual framework describing factors influencing intentions to increase whole grain provision in Thai elementary schools. Participants were predominantly female (93.1%) and highly educated (89.7% with a bachelors degree or higher). Most supported incorporating whole grains into school meals, citing their health benefits for schoolchildren. However, participants reported low WG intake among schoolchildren, attributable to limited availability at both schools and homes. Two primary barriers to whole grain provision were identified. The first was student-level resistance, including unfamiliarity and sensory aversions, particularly toward brown rice. The second involved systemic challenges, including the absence of regulatory guidance promoting whole grain inclusion and operational constraints related to contracted food services and inflexible menu systems. Multi-level engagement among schools, households, and government agencies was identified as a key facilitator of increased whole grain provision in school meals.? These findings indicate that although teachers and cooks are receptive to whole-grain provision in school meals, translating this support into practice will require coordinated, multisectoral action to address persistent structural barriers at the student, school, and policy levels. Future research should incorporate childrens perspectives and examine a broader range of school settings to inform the design of effective, sustainable strategies for whole grain integration.

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Uncovering Social Media Influencers' Health Posts: A Youth-Driven Mixed Method Study

Gell, S.; Engel, E.; Karsay, K.; Heiss, R.

2026-10-14 public and global health 10.64898/2026.10.13.26365375 medRxiv
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Social media influencers serve as a key source of health information for adolescents but often lack expertise, have commercial motives, and may spread misleading or harmful content. This study examines the health-related content shared by influencers, the prevalence of advertising, and how adolescents evaluate potential benefits and risks. Using a mixed-methods approach, we employed a quantitative descriptive method involving citizen science (Study 1) and a qualitative content analysis (Study 2). In Study 1, 336 adolescents from 16 Austrian schools documented and categorized 2,147 posts from 255 influencers. The most common topics included sports and fitness (50.5%), beauty ideals (29.6%), food and nutrition (27.6%), and cooking (19.1%). Although advertisements appeared in 41.5% of posts, adolescents rated 60.4% of them as beneficial and only 4.5% as harmful. The qualitative analysis of a subsample of the 90 most prominent posts showed that adolescents appreciated motivational aspects (e.g., healthy eating) but often overlooked problematic elements such as misleading claims, sexualized body ideals, and the linking of health messages to commercial products. Enhancing persuasion knowledge and critical thinking through education, along with stricter regulation of harmful products, is crucial to safeguarding youth online.

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Mid-Life Leisure-Time Physical Activity Is Associated With Lower Hip Fracture Risk In UK Biobank

Rolls, C.; Faber, B. G.; Clark, E. M.; Dawes, H.; Munafo, M. R.; Tobias, J. H.

2026-10-11 epidemiology 10.64898/2026.10.08.26365023 medRxiv
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Leisure time physical activity (LTPA) in mid-life may have beneficial effects on risk factors for hip fracture in later life. Conversely, physical activity may increase fracture risk through risk of injury, and the optimal amount of physical activity for reducing hip fracture risk remains unclear. We explored the associations between volume and intensity of LTPA in mid-life, and subsequent risk of hip fracture ascertained from linked health data. This prospective observational study used middle aged adults aged 40- 65 years from UK Biobank. LTPA volume (LTPAv) was derived from self-reported walking, moderate and vigorous activity at baseline (2006- 2010). Cox proportional hazard and Fine-Gray sub-distribution models were used to estimate the association between activity and hip fracture, which was sex-stratified. From 324,284 participants with complete data 53% were female and mean age at baseline was 54.5 (SD 7.3). Across 16 years of follow-up there were 2,674 hip fractures. In terms of LTPA volume, the lowest risk of hip fracture occurred in quintile 3 for women (HR 0.78, 95% CI 0.67-0.91), and men (HR 0.74, 95% CI 0.60- 0.90), relating to approximately one hour/day of leisure time physical activity. When activity intensities were examined separately, the lowest estimated hazards were observed for vigorous activity, at quintile 4 in women (HR 0.65, 95% CI 0.55 - 0.76) and quintile 3 in men (HR 0.64, 95% CI 0.52- 0.79), corresponding to approximately 60- 90 minutes of vigorous activity per week. In conclusion, moderately high volumes of mid-life physical activity, particularly vigorous activity, were related to lower risk of subsequent hip fracture, but these relationships appear to attenuate at higher volumes.

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Associations of individual exposure to particulate matter with next-day physical activity and sedentary behaviour in older adults: a micro-longitudinal study

Bloomberg, M.; Jones, M.; Brocklebank, L.; Zaninotto, P.; Steptoe, A.

2026-09-25 epidemiology 10.64898/2026.09.23.26363783 medRxiv
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Background Staying physically active is essential for healthy ageing. Exposure to high levels of air pollutants such as particulate matter (PM) is associated with less active, more sedentary lifestyles in older adults. Whether results extend to typical fluctuations in daily PM exposure is unclear. We examined associations of higher-than-usual personal exposure to PM (PM2.5 and PM10) with next-day movement behaviour in older adults, assessed using concurrently worn personal air quality monitors and accelerometers. Methods The present study used 304 days of data from 67 adults aged 50-85 years living in the UK. For five days, participants wore accelerometers 24-hours per day and personal air quality monitors during waking hours. Average daily time spent in movement behaviours (moderate-to-vigorous physical activity [MVPA], light physical activity [LPA], sedentary behaviour [SB]) and step count was extracted from accelerometers, and average daily exposure to PM2.5 from personal air quality monitors. PM10 was examined in secondary exploratory analyses. We used linear mixed models to examine within-person associations of deviation from usual PM exposure with next-day movement outcomes, with estimates presented for 'usual' (individual mean) and 'higher-than-usual' (+1 interquartile range, equivalent to 2.6 g/m3 beyond individual mean PM2.5 exposure and 2.8 g/m3 beyond individual mean PM10 exposure) exposure. Analyses were repeated using area-based PM estimates. Results Compared with usual exposure, higher-than-usual PM2.5 was associated with 8 minutes less LPA (95% CI=-14 to -2) and 483 fewer steps (-855 to -82) on the following day. Exposure to higher than usual PM10 was associated with 8 minutes less LPA (-13 to -3), 8 minutes more SB (0 to 15), and 412 fewer steps (-739 to -85) on the following day. There was no association with MVPA, and no associations when area-level PM estimates were used as opposed to estimates from personal air quality monitors. Conclusions Typical daily variability in PM exposure in a setting with relatively low overall PM levels was associated with modest next-day differences in movement behaviour in older adults. Higher-than-usual PM exposure was associated with less next-day activity and more sedentary time. Personal monitoring may be important for capturing short-term exposure-behaviour associations. Trial registration N/A

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Proof-of-implementation of the SMART2D intervention: findings from a cluster randomised feasibility trial for prevention and control of type 2 diabetes in socio-economically disadvantaged neighbourhoods in Stockholm, Sweden

Daivadanam, M.; Sidney Annerstedt, K.; Alveson, H.; Timm, L.; Johan Sundberg, C.; Delobelle, P.; Olmen, J. V.; Absetz, P.; Guwatudde, D.

2026-10-02 public and global health 10.64898/2026.09.30.26364359 medRxiv
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Background Type 2 diabetes (T2D) disproportionately affects socioeconomically disadvantaged communities. Evidence on the feasibility and effectiveness of prevention and self-management strategies in complex contexts remains limited. Objective To report effectiveness outcomes from a feasibility trial comparing the SMART2D intervention with routine primary care for T2D prevention and control in two neighbourhoods in Stockholm. Methods A cluster-randomized feasibility trial with hybrid type 1 design was conducted in two neighbourhoods among individuals at high risk of T2D (n=84) or with diagnosed T2D (n=58), allocated to an integrated care arm (n=70; personal coaching and community outreach) or facility-only arm (n=72; routine care). Primary outcomes were glycaemic control (participants with T2D) and HbA1c reduction (participants at high risk of T2D); secondary outcomes were retention to care and diabetes incidence (participants at high risk of T2D). Analysis used intention-to-treat principles: difference-in-differences with mixed-effects models for HbA1c reduction, and modified Poisson regression (IRR, 95% CI) for other outcomes. Results Among participants with T2D, glycaemic control (adjusted IRR=0.92, 95% CI=0.89-0.95) and retention to care (adjusted IRR=0.91, 95% CI=0.91-0.92) were significantly lower in the integrated care arm. Among participants at high risk of T2D, integrated care showed a marginally significant, greater HbA1c reduction (adjusted 2.02, 0.20-3.84) and significantly higher retention to care (adjusted IRR=1.22, 1.15-1.29), plus fewer incident diabetes cases (0 vs. 2 in facility-only). Conclusions Integrated care (personal coaching, community outreach) benefited HbA1c reduction and retention among participants at high risk of T2D, whereas facility-only care improved glycaemic control and retention among participants with T2D.

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Population-Based Prevalence of Overweight and Obesity in German Youth: Findings from MoMo 2.0 and Comparison with KiGGS

Lazarides, C.; Kuhnert, R.; Schienkiewitz, A.; Tschuschke, L.; Klos, L.; Fiedler, J.; Wolbring, L.; Hanssen-Doose, A.; Volk, C.; Niessner, C.; Loss, J.; Voelkle, M. C.; Woll, A.

2026-10-02 epidemiology 10.64898/2026.10.01.26364513 medRxiv
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Objective: Overweight and obesity in childhood and adolescence are major risk factors for health problems across the lifespan. This manuscript reports the current prevalence of overweight and obesity among children and adolescents aged 4-17years living in Germany and compares them with previous population-based results. Methods: A representative, cross-sectional sample of 4-17-year-olds was drawn following a multistage sampling process. Analyses are based on weight and height of 3,978 individuals measured in the field by trained test instructors between 2023-2025. Overweight and obesity classification was defined using age- and sex-specific body-mass-index percentiles. To allow for comparability of prevalence estimates derived from previous assessment waves and other panel studies dating back to 2005, an alignment factor was derived using an inverse probability of participation weighting approach. Together with sampling weights, the alignment factor was applied to obtain current, representative prevalence estimates of overweight and obesity. Results: The aligned, weighted prevalence of overweight and obesity was 16.1% (95%CI[14.5-17.9%]), whereas prevalence of obesity was 6.7% (95%CI [5.5-8.1%]). Age- and sex-specific prevalence rates are reported and compared to previous waves. Conclusions: The current prevalence of overweight and obesity in children and adolescents aged 4-17 years living in Germany remains stable over the past two decades.

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Does active travel behaviour moderate the association between the built environment and depression?

Sanders, F.; Baltramonaityte, V.; Whitmarsh, L.; Walton, E.

2026-10-11 public and global health 10.64898/2026.10.08.26364859 medRxiv
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Background: Built environment characteristics have been associated with depressive symptoms, whilst active travel behaviour is linked to improved mental health. However, it remains unclear whether active travel buffers associations between increased exposure to the built environment and worse mental health. Methods: In this pre-registered study, participants were 10,310 mothers (mean age = 28.11, SD = 4.83) participating in the Avon Longitudinal Study of Parents and Children (ALSPAC). A latent built environment factor was measured at study enrolment, active travel behaviour at a 2-year follow-up, and depressive symptoms at a 4-year follow-up. Moderation was examined using adjusted linear regression models including an interaction term between the built environment factor and active travel behaviour. Results: The built environment factor was positively associated with depressive symptoms ({beta} = 0.023, p = .012). Active travel behaviour was not associated with depressive symptoms ({beta} = -0.002, p = .854) and did not moderate the association between the built environment factor and depressive symptoms ({beta} = -0.002, p = .865), after adjusting for covariates, including age, familial depressive history, socioeconomic risk factors, physical activity, baseline depressive symptoms and smoking. Conclusion: Contrary to expectations, active travel behaviour does not modify associations between the built environment and depressive symptoms. These findings provide no evidence that active travel mitigates mental health risks associated with the built environment in this population.

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Dietary Patterns and Cardiovascular Risk in Adult Survivors of Childhood Cancer: Findings From the SCCSS-Nutrition Study

Li, R.; Revuelta Iniesta, R.; Barker, A. R.; Chatelan, A.; Leuenberger, L. M.; Shoman, Y.; Spycher, B. D.; Belle, F. N.

2026-09-23 nutrition 10.64898/2026.09.22.26363621 medRxiv
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PurposeTo identify dietary patterns among adult childhood cancer survivors (CCSs), examine their determinants, and assess whether they differ according to cardiovascular disease (CVD) risk profiles. MethodsCCSs from the Swiss Childhood Cancer Survivor Study diagnosed before age 21 years (1976-2005), surviving [≥]5 years and aged [≥]18 years in 2017, completed a food frequency questionnaire (SCCSS-Nutrition). Factor and hierarchical cluster analyses of 52 food groups identified dietary patterns. We categorised CCSs as having CVD, CVD risk factors (obesity, hypertension, diabetes, high cholesterol), or being CVD risk-free. Multinomial logistic regression assessed associations between dietary patterns and CVD risk profiles. ResultsAmong 802 CCSs (median age: 35 years; IQR: 29-41; 50% male), we identified five dietary patterns: Mediterranean-inspired diet (22%), Western indulgence diet (38%), Western sweet & fatty diet (26%), restrained indulgence diet (9%), plant-based & alcohol-rich diet (6%). Male sex, younger age, German-speaking region, smoking, and living with others were associated with Western indulgence, Western sweet & fatty, and restrained indulgence diets. Higher Swiss socioeconomic position (Swiss-SEP) and education, and not having children, were associated with the plant-based & alcohol-rich diet, higher Swiss-SEP was also associated with the Western indulgence diet. No associations were observed between dietary patterns and CVD risk profiles. ConclusionsDietary patterns among adult CCSs were socially patterned and differed according to sociodemographic and lifestyle characteristics, but were not associated with CVD risk profiles. Implications for Cancer SurvivorsDietary counselling and broader lifestyle support should be considered as part of long-term survivorship care for CCSs.

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Real-World Twelve-Month Weight Loss Outcomes in a Comprehensive Obesity Care Program Utilizing Individualized Nutrition Therapy and Incretin-Based Obesity Medications

Athinarayanan, S.; Zoller, A. R.; Bergethon, K. E.; Goss, A. M.; Gower, B. A.

2026-10-13 nutrition 10.64898/2026.10.09.26365158 medRxiv
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Background: Incretin-based obesity medications (IOMs) produce substantial weight loss, but the incremental benefit of structured nutritional therapy when integrated with pharmacotherapy remains unclear. Objectives: To compare 12-month weight-loss outcomes between individualized carbohydrate-reduced nutritional therapy combined with IOMs (VINT+IOM) and IOM-based care without structured nutritional therapy (IOM only). Methods: This retrospective cohort study evaluated 4,269 adults enrolled in a comprehensive telemedicine obesity care program (VINT+IOM, n=1,658; IOM only, n=2,611). Both pathways included clinician-guided medication management and behavioral coaching. The primary analysis focused on GLP-1-naive participants receiving either semaglutide or tirzepatide without switching medications during follow-up. Adjusted weight changes were estimated using longitudinal linear mixed-effects models accounting for baseline demographic and clinical characteristics. Additional analyses evaluated weight-loss responders, prior GLP-1 exposure, and medication utilization. Results: Among GLP-1-naive semaglutide users, adjusted 12-month weight loss was greater with VINT+IOM than IOM only (30.7 vs. 24.1 lb; P=0.01), with corresponding observed weight loss of 13.3% versus 11.1%. Among tirzepatide users, adjusted weight loss was 45.9 versus 34.4 lb (P=0.003), with observed reductions of 19.7% versus 15.6%, respectively. Weight-loss responder rates consistently favored VINT+IOM. In the overall cohort, including GLP-1-naive participants, those with prior GLP-1 exposure, and participants with varying medication trajectories, adjusted weight loss was 29.4 versus 21.5 lb (P less than 0.001), with observed reductions of 12.7% versus 9.6%. Greater weight loss with VINT+IOM was also observed among participants with prior GLP-1 exposure. Weight loss continued between 6 and 12 months in both pathways. Medication coverage was high, with approximately 80% of participants achieving a proportion of days covered of at least 80% in both pathways. Conclusions: Integrating individualized carbohydrate-reduced nutritional therapy with IOM-based care was associated with greater 12-month weight loss than IOM-based care without structured nutritional therapy. These real-world findings support further evaluation of individualized nutritional approaches as an adjunct to incretin-based obesity pharmacotherapy.

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Nutritional awareness, eating behaviour, body mass index, and estimated resting metabolic rate in physical education students: A descriptive, analytical and correlational study

QADUMI, A. a.; Qadumi, R. A.; Qadoume, A. A.; Al-Atrash, M.; Qutob, R. K.; Amad, S. H.; Qadoumi, M. A.; Nairat, Q. M.; Qaddoum, A. K.

2026-10-08 nutrition 10.64898/2026.10.06.26364876 medRxiv
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Background: University life can influence food choice even among physically active students. This study examined nutritional awareness, emotional, external, and restrained eating, body mass index (BMI), and estimated resting metabolic rate (RMR) in physical education students, and assessed differences by sex and academic level. Methods: A descriptive, analytical and correlational design was used. The sample included 160 physical education students (95 women and 65 men; mean age 20.42 {+/-} 1.53 years) from An-Najah National University. Nutritional awareness was assessed with a 15-item scale, and eating behaviour with the 33-item Dutch Eating Behavior Questionnaire. BMI was calculated from measured height and body mass, and RMR was estimated using an equation developed for athletes. Correlations, group comparisons, robust interaction models, and hierarchical regression were applied. Results: Nutritional awareness was high (3.73 {+/-} 0.81), whereas emotional (3.11 {+/-} 1.18), external (3.20 {+/-} 0.95), and restrained eating (3.25 {+/-} 1.11) were moderate. Higher awareness was associated with less emotional (r = -0.617) and external eating (r = -0.652), but greater restrained eating (r = 0.644; all q < 0.001). These associations remained after adjustment. Men reported more external eating, while women reported more restrained eating. Eating patterns also varied by academic level. BMI and estimated RMR showed weaker and less consistent associations with eating behaviour. Conclusions: Nutritional awareness was closely associated with reported eating behaviour, whereas BMI and estimated RMR were less informative. Sex and academic-level differences suggest that nutrition education for physical education students may be more useful when adapted to specific behavioural patterns. The findings represent associations and group differences and do not establish causal relationships. Keywords: physical education students; nutritional awareness; eating behaviour; emotional eating; external eating; restrained eating; body mass index; resting metabolic rate

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Impact of conditional mobile data credits on caregivers use of an early childhood digital health intervention: a nested cluster-randomized controlled trial in Andean Peru

Hatch, S. F.; Aguilar, L.; McCoy, D.; Fink, G.; Hinckley, K.; Castellanos, A.; Alvarado, M.; Gastiaburu Cabello, M. C.; Hartinger, S.; Jäggi, L.

2026-10-09 public and global health 10.64898/2026.10.07.26364726 medRxiv
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As internet and mobile phone access increases, digital health interventions are increasingly used to support remote and low-resource populations. In many settings, the health impact of digital interventions is constrained by limited or short-lived engagement. We tested if conditional mobile data credit incentives increase digital intervention engagement within a digital intervention trial. This nested cluster randomized controlled trial was conducted with caregivers of children 3-9 months at baseline. Of 72 neighborhood clusters from the treatment arm of the parent trial (evaluating a digital early childhood development intervention), 20 were randomly assigned to treatment and 52 as controls. Eligible participants had a phone provider through which mobile data credits could be most affordably administered. Treated participants received around 250 MB mobile data credits every two weeks, conditional upon using the digital intervention at least once in the same period. Credits were digitally administered via a third-party service. Digital intervention engagement (primary outcome) was monitored continuously until endline data collection approximately 2 years after assignment. Secondary outcomes included caregivers views, behaviors, and early childhood development. We used intent-to-treat analyses to assess all outcomes. This trial was registered as NCT05202106 at clinicaltrials.gov and was completed in 2025. Participants were recruited between September 2021 and March 2023 (N Treatment = 147; N Control = 333). Conditional mobile data credits extended engagement with the digital early childhood development intervention by 6.50 weeks on average (treatment mean = 26.19 weeks, control mean = 19.69; p=0.011). No significant impacts were identified on secondary outcomes. As such, mobile data credits may be a cost-effective way for increasing caregiver engagement with digital health intervention in low resource settings.

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An Evolution of Pilot Nutrition Programs to Improve Diet Quality among Older Veterans

Giffuni, J.; Fique, M.; Cassatt, S.; Joyce, K.; Krasniewski, L.; Addison, O.; Dennis, E.

2026-09-29 nutrition 10.64898/2026.09.28.26364174 medRxiv
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Despite the numerous benefits associated with higher dietary quality, many older Veterans do not meet national dietary recommendations. Existing programs are not typically tailored for older Veterans who may experience physical and environmental limitations that hinder their ability to access and prepare healthy foods. This project piloted the incorporation of age-friendly, tailored, virtual nutrition education into an existing health promotion program for older Veterans. Programming followed an iterative design process over two years. Year 1 included 14 weeks of virtual nutrition education on healthy aging paired with weekly produce bags and recipe suggestions. In Year 2, virtual nutrition education shifted to more hands-on learning emphasizing basic meal preparation and adaptive cooking strategies for mobility limitations. Produce distribution in Year 2 shifted to a farmer's market model, based on feedback from year 1, allowing participants to self-select items. Primary outcomes included program satisfaction, dietary intake assessed via 24-hour recall to calculate the Healthy Eating Index (HEI-2015), and health-related quality of life (PROMIS Global Health). Findings demonstrate the feasibility and acceptability of a virtual nutrition program incorporating age-friendly cooking instruction and adaptive strategies to improve dietary quality among older Veterans.

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Effects of Dish Name, Visible Amount, Persona, and Explicit Instruction on Energy Estimates From Food Photographs by 26 Vision-Language Models: Comparative Evaluation Study

Nakagawa, S.; Yamamoto, A.

2026-10-13 health informatics 10.64898/2026.10.09.26365134 medRxiv
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Background: Vision-language models (VLMs) are being considered for estimating energy intake from meal photographs. Prompt descriptions such as a Japanese-dietitian persona shift the estimates, suggesting their use for calibration; what the estimates rest on was unknown. Objective: We examined whether prompt descriptions can serve as calibration, at which training stage responses to a nationality persona and to an amount instruction arise, and whether estimates follow the visible amount or one associated with the identified dish. Methods: Eleven commercial and 15 open-weight models were evaluated on NutriImage (887 Japanese single-dish photographs) and SNAPMe (1,134 US meal photographs) under eight prompt conditions (no description, five personas, and smaller- or larger-portion instructions). With one model, images were cropped or replaced by the dish name. Before- and after-meal photographs of 804 meals (ACETADA) were estimated. Pre-trained and post-trained weights of Gemma 3 and InternVL3.5 8B were compared by likelihood scoring. Prompts were compared with numerical calibration. Results: Where the dish was named as in the full image, a 25% crop changed neither the median absolute percentage error (MedAPE; 33.8% vs 34.4%) nor the persona shift (-20 vs -20 kcal); dish names alone gave similar accuracy (MedAPE 31.7%); nearly empty trays still received 39%-75% of the before-meal estimate, often described as already eaten. Between models, the persona shift was related to baseline bias (r = -0.77) and less to instruction following (r = -0.36); the instruction shift showed the reverse (r = -0.14 and -0.95). In Gemma 3, the Japan-US contrast was 2-4 times larger before post-training, and the instruction response 2-4 times larger after it (InternVL3.5 8B: 3 and 1.4 times). Across images, the Japan-US contrast was uniform on US meals and, for Japanese dishes in the commercial models, Gemma 3, and Qwen3-VL 32B, larger where overestimated. In these models, the persona lowered MedAPE for Japanese dishes as much as, or slightly more than, subtracting the mean bias, and no more than dividing by a ratio; on US meals it did not; in open-weight families that responded little, only numerical calibration lowered error. The smaller-portion instruction raised MedAPE in models with little bias (eg, 30.0% to 50.2%). Conclusions: In the model examined most closely, the estimates behaved as if anchored on an amount associated with the identified dish and only partly corrected by the visible amount. Prompt descriptions moved them by amounts depending on model and cuisine, not on the correction needed; a persona is therefore not proposed as a general means of calibration. In a facility, the findings suggest showing the identified dish for correction, calibrating by a ratio measured on reference meals with the deployed model, keeping amount statements out of the prompt, and not deriving intake from before-after-meal differences.

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Targeted Free Swimming for Women, Girls, and Older Adults in Tower Hamlets: A RE-AIM Evaluation Study Protocol

Clements, K.; Todorova, Y.; Makawa, A.; Asamoah, P. E.; Lester, P.; Ngina, D. M.; Sherar, L.

2026-10-07 public and global health 10.64898/2026.10.05.26361900 medRxiv
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Across the UK, older adults in deprived areas like Barnsley are spending more of their lives in poor health. Alongside increased loneliness, this creates barriers to leading active healthy lives that can lead to decreases in the quality of life of residents and increased pressure on healthcare services. To address these issues, Barnsley Council brought together over 80 providers of physical activity classes for adults aged 50 and over as part of a joined up partnership called the Barnsley Older People Physical Activity Alliance (BOPPAA). The evaluation will explore how effectively the joined up partnership (BOPPAA) works in helping older adults lead active health lives by collecting information on involvement in the classes, and speaking to residents and organisations to get their thoughts and opinions. The findings will be used to help understand how BOPPAA can be improved to better meet the needs of the local population.

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Does handgrip strength improve cardiometabolic risk stratification beyond detailed body composition? NHANES 2011-2014 with temporal validation

Zhan, X.; Shen, M.; Zhang, Y.; Mao, X.

2026-10-12 epidemiology 10.64898/2026.10.09.26365176 medRxiv
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Background: Handgrip strength is associated with cardiometabolic abnormalities, but whether it adds information once detailed adiposity and muscle mass are known is unclear. Methods: We studied adults aged 40-59 years from NHANES 2011-2012 (development, n=508) and 2013-2014 (temporal validation, n=616). The outcome was at least two of four non-adiposity abnormalities (elevated blood pressure, fasting glucose or triglycerides, or low HDL cholesterol); waist circumference was not part of the outcome. A prespecified feature ladder added DXA body fat percentage and visceral adipose tissue to age, sex, BMI and waist circumference (M1), then appendicular skeletal muscle index (M2), then absolute (M3A, primary) or weight-normalised (M3B) grip strength. Logistic regression was primary; elastic-net and XGBoost were supportive. Development performance used nested cross-validation; frozen models were scored once in the validation cohort. Paired increments used 2000 stratified bootstrap resamples. Results: The outcome occurred in 249 (49.0%) and 277 (45.0%) participants. Adding adiposity increased the logistic regression AUC by 0.0209 (95% CI 0.0024-0.0402) in development and 0.0209 (0.0032-0.0375) in temporal validation. Adding absolute grip strength to M2 changed the AUC by -0.0046 (-0.0107 to 0.0013) and 0.0045 (-0.0009 to 0.0098), respectively. All 12 grip-strength AUC increments across algorithms, definitions and cohorts had intervals that included zero. Calibration was unchanged and the incremental net benefit was not consistently positive. Model attributions to grip strength varied by algorithm. Conclusions: In middle-aged adults, detailed adiposity, but not grip strength, added reproducible information for concurrent cardiometabolic risk stratification beyond conventional anthropometry and muscle mass.